| Team | Team Total | O/U |
|---|---|---|
| Buffalo Bills | 31 | 46.5 |
| Detroit Lions | 27 | 45.5 |
| Philadelphia Eagles | 26 | 48.5 |
| Baltimore Ravens | 25 | 48.5 |
| Los Angeles Rams | 25 | 48.5 |
Welcome to our breakdown of the best DraftKings NFL Week 4 picks, stacks, and DFS strategy for the main slate. We’ll cover our top DraftKings plays for Week 4, including must-target offensive stacks, high-upside game stacks, sharp bring-backs, and value one-off plays. Whether you’re building lineups for tournaments or cash games, these NFL Week 4 DraftKings recommendations will help you gain an edge and maximize your DFS success.
The table represents the teams with the highest implied totals on the slate. These are subject to change through the week. Check out FantasyLabs free vegas dashboard for any changes.
New Orleans Saints at Buffalo Bills
We kick off the slate with the Buffalo Bills’ offense, which owns a team total far higher than any other squad this week. That typically signals multiple fantasy-relevant players, but the key is identifying the best way to attack. James Cook immediately stands out as the premier option, and he’s likely to be one of the more popular running backs on the slate.
Cook has logged 53 carries through three weeks (18 per game) while adding three targets per contest, giving him both volume and versatility. He ranks 5th in red-zone touches (14), with 4 of those coming at the goal line, and he’s converted at an elite level, leading the league in total touchdowns. The advanced metrics back up his production as well—2nd in rushing yards, 3rd in fantasy points per game, and 15th in both receptions and receiving yards among running backs.
From a DFS perspective, Cook offers a high floor for cash games and slate-breaking upside in tournaments, making him one of the top running back plays on the board this week.
| Player | Price |
| Josh Allen | $7,700 |
| James Cook | $7,100 |
| Keon Coleman | $5,600 |
| Alvin Kamara | $6,100 |
| Chris Olave | $5,100 |
There is some concern that the Bills could build an early lead, which might limit James Cook’s involvement later in the game. That’s worth keeping in mind when making roster decisions. Shifting to Josh Allen, we already know his fantasy value—he’s an elite dual-threat quarterback who can win with both his arm and legs. Through three weeks, Allen has attempted 99 passes (33 per game) and leads the league in red-zone attempts. He’s always in play for DFS, and this week is no exception.
On the other side, two intriguing options stand out: Alvin Kamara and Chris Olave. The Bills’ defense has been far more vulnerable on the ground than through the air, giving up a league-worst 156 rushing yards per game. We saw Derrick Henry carve them up for 169 yards and two scores in prime time, which raises the case for Kamara. He’s commanding a strong 79.2% snap share and averaging 19 touches per game, but the efficiency hasn’t followed—he’s putting up just 12.1 fantasy points per game so far. He’s a volume-based GPP dart, but tough to trust in cash.
Olave, on the other hand, pops as a strong value. He ranks 2nd in receptions per game (7.7) and leads the league in targets (12+ per game), commanding a massive 31.9% target share. Despite averaging only 13.2 fantasy points per game, much of that inefficiency stems from quarterback play, not opportunity. Add in his 9 red-zone targets (top 10 in the league) and a game script where the Saints will likely be forced to throw at a high rate, and Olave sets up as one of the best mid-range wide receiver plays on the slate, especially for tournaments.
Favorite Stack: Secondary Game Stack
James Cook + Chris Olave
Los Angeles Chargers at New York Giants
Justin Herbert stands out as one of the top quarterback options on this slate, and the advanced metrics only strengthen the case. He leads the league in passing yards (286.7 per game) and ranks second in air yards (338.3 per game), showing both volume and aggressiveness. Herbert also sits inside the top 10 in deep-ball attempts and red-zone usage, giving him multiple paths to a ceiling performance.
Efficiency adds even more appeal. Herbert ranks top-6 in yards per attempt (8.0) and is second in QBR (81.6), a combination that signals strong upside if game conditions stay favorable. From a DFS standpoint, Herbert is firmly in play for tournaments, where his elite ceiling and strong stacking options make him my favorite quarterback on the slate for GPP builds.
| Player | Price |
| Justin Herbert | $6,300 |
| Ladd McConkey | $6,500 |
| Omarion Hampton | $5,900 |
| Quentin Johnston | $5,500 |
| Keenan Allen | $5,300 |
One of the key challenges in targeting this offense for DFS is deciding which pass catcher to prioritize. Ladd McConkey carries the highest price tag at $6,500, but Keenan Allen offers strong value at $5,300, especially considering he leads the team with 28 targets (7th in the league). McConkey has 21 looks and Quentin Johnston 24, which highlights Herbert’s tendency to spread the ball around.
Allen’s reduced snap share (around 60% compared to the 80% range for McConkey and Johnston) is worth noting, but he leads the team in red-zone targets with six. Johnston is right behind with five, while McConkey has just one. From a DFS perspective, Allen projects as the safest option for cash games thanks to his volume and role near the goal line, while Johnston provides GPP-winning upside at lower ownership. McConkey, meanwhile, makes sense as a leverage play if the field leans heavily toward Allen’s price discount.
The table below lays out the key metrics to help guide roster construction and contest strategy.
| PLAYER | TARGETS | RECEPTIONS | DEEP TARGETS |
| Ladd McConkey | 21 ( 7 / PG) | 15 (5 / PG) | 1 (0.3 / PG) |
| Quentin Johnston | 24 (8 / PG) | 14 (4.7 / PG) | 6 (2 / PG) |
| Keenan Allen | 28 (9.3 / PG) | 19 (6.3 / PG) | 3 (1 / pg) |
When comparing the matchups, it’s clear that Keenan Allen and Justin Herbert still have strong chemistry. The Giants rank 28th against the pass, allowing an average of 252 yards per game, 405 total yards (31st), and 27.7 points (25th). This creates a “pick-and-choose” situation at wide receiver, where contest selection and ownership considerations will play a key role.
Allen remains the safe option, but Quentin Johnston brings slate-breaking upside with his speed, while Ladd McConkey also offers potential and could have his breakout week here.
In the backfield, Omarion Hampton deserves attention with Najee Harris now on IR. Last week, Hampton saw a significant workload increase with 19 carries and 7 targets—nearly triple his usage from the prior game. He now finds himself in a prime matchup against the Giants’ defense, which is surrendering 153.3 rushing yards per game, ranking 31st in the league.
Overall, this offense provides several strong, serviceable options to target this Sunday.
FAVORITE STACK: QB + 2 W/ BRING BACK
Justin Herbert + Ladd McConkey + Keenan Allen + Skattebo
INDIANAPOLIS COLTS AT LOS ANGELES RAMS
One of my favorite games on the slate is the Rams vs. Colts, and I’m clearly not alone—the line has been moving up throughout the week. A big storyline has been the resurgence of Daniel Jones, who just a short time ago was someone we targeted defenses against in New York due to turnovers. Now with the Colts, he ranks 3rd in passing yards (816), 2nd in yards per attempt (9.3), and is throwing nearly 30 times per game. Jones also adds value with his legs, averaging three red-zone carries per game and ranking 2nd among QBs in rushing touchdowns (3), matching his passing touchdown total. On the Rams’ side, Matthew Stafford looks healthy, throwing for 739 yards (9th), 5 touchdowns (7th), and averaging 31 attempts per game. With the Colts averaging 34.3 points per game and the Rams at 24.3, both teams can move the ball, creating one of the slate’s most explosive game environments.
| PLAYER | PRICE |
| Puka Nacua | $7,900 |
| Jonathan Taylor | $7,500 |
| Kyren Williams | $6,300 |
| Davante Adams | $6,200 |
| Michael Pittman Jr | $5,100 |
| Tyler Warren | $4,600 |
The offensive talent here is undeniable. Puka Nacua has emerged as a fantasy superstar, averaging 11.7 targets per game with a massive 37.6% target share and over 100 air yards per game. He leads the league in receptions and receiving yards while ranking 4th in yards after catch, producing 24.5 fantasy points per game. On the other side, Jonathan Taylor continues to dominate, leading the NFL in rushing yards (338), carries (60), and fantasy points per game (25). His involvement isn’t limited to the ground game either, with 3 targets and 31 receiving yards per game, plus a league-high total in touchdowns.
Davante Adams is another name that shouldn’t be overlooked in this spot. With 29 targets through three weeks (9.7 per game), a 31.2% target share, and 8 red-zone looks, he brings huge GPP upside and serves as a strong leverage play off Nacua. Finally, TE Tyler Warren offers sneaky value, averaging 7 targets per game with a 24% target share and an impressive 25% target rate in this offense—making him a solid pivot off Taylor at lower ownership.
FAVORITE STACK: SECONDARY GAME STACK
ADAMS + WARREN
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